Duke University’s impact on medical research included mitigating pediatric poisonings across the country. Duke pediatrician Jay Arena led the push for drug companies to develop childproof safety caps for children’s “candy” aspirin. In a letter to fellow physicians, he wrote, “The adoption of such a closure could mean a saving of many small children's lives from the accidental ingestion of drugs.” With nationwide design testing and the first advertisements in 1958, St. Joseph's aspirin was the first pharmaceutical sold with a safety cap.