Seeing the Invisible: 50 Years of Macromolecular Visualization
Representations of Cu,Zn Superoxide Dismutase (SOD)
The ribbon visualization is a very effective way to illustrate the elegant and beautiful complexity of how different proteins fold up to play their biological role.
Large, colored ribbon drawing of SOD
Jane enlarged her pen-and-ink ribbon drawing of SOD (PDB file 1sod) and colored it to give it an even clearer three-dimensional feel. Blue arrows are the beta strands, connected in an antiparallel Greek key topology. The active-site copper and zinc are shown by discs of those metals.
SOD poster image for 2007 Protein Society meeting
This composite image shows the SOD ribbon drawing at left, electron density and all-atom contact dots for the dimer interface in center, and at right the Mage computer-drawn ribbons for the two dimer molecules in the repeating asymmetric unit of the crystal (orange/yellow and blue/green).
(left) Poster for the ASBMB/Biophysical Society in 1992 with an image of the stained glass window containing the SOD drawing; (right) a photograph of the original stained glass window.
Laser-etched SOD ribbons
This three-dimensional representation shows the two dimer molecules in the crystal asymmetric unit of SOD.
Foam model of SOD at low resolution
SOD dimer electron density at low resolution (5.5Å), made of glued-together layers of styrofoam. This crude model nonetheless shows the dimer contact, and the β-barrels (a type of β-sheet) as cylindrical slabs of density. [Thomas et al. 1974 J. Biol. Chem. 249: 5677]